Han Sung Ju
Seoul National University Hospital, South Korea
Title: Cognitive improvement by food substitutes using PhytoMeal, Pitfalls for Neuropsycholgical testing
Biography
Biography: Han Sung Ju
Abstract
Increasing aging population accelerate the prevalence of patients with dementia. They were initially complaining or unaware their cognitive decling, thus proper neuropsyological evaluations are sometimes missed. Recently, in addition to the developing medicine that targeting the amyloid plaque in case of Alzheimer’s disease, there are several important attention for the exploring the functional food that improve or at least delayed the progression of cognitive decline. Among the candidate for the Salicornia Europaea, a plant in the ocean,-the plant cannot grow in the salted environment-had been selected and explored the possibilities for its anti-choline esterate inhibitory effect, that lead to the improve the neuropsycholgical performance. In vitro and in vivo test had been shown effective and clinical trial with several series of psychological tests have be on going. To be able to use in human, efficacy and safety of this Salicornia Europaea should be of importance in order to review from KFDA (Food and Drug administration). Currently, improvement of K-MMSE and ADAS-cog are main primary endpoints in Korea. However, determining process selecting proper psychological test were not organized. Therefore, there can be possible limitation that mask the real efficacy of functional food approvement. If the result was not significant, different psychological tests should be remained for further evaluation of endpoint. International standard for applying psychological evaluation would be of benefit. More efficient detailed or reliable evaluation of psychological analysis that can be applied to the development of cognitive-enhancing medicinal food.